Page layout rules may not always work for you, but at least it can spare you from common page layout ailments. It can give you the least amount of trial and error, as close to a perfect page layout as anyone can get.
In general, these are the guidelines to follow:
Alignment. Ensure that text and images align. Everything on the page should align with something else. Break alignment only for emphasis.
Graphic Design. If graphic designs are well-designed, they will look just as good upside down as they do right side up.
Margins. Margins should not be the same on all sides of a publication. In facing-page documents, the inside margin should be smaller than the outside margin. The bottom margin is usually larger than any other margins. Margins should be sized progressively from smallest to largest: inside, top, outside, bottom.
Rule of Thirds. Visually divide your page into thirds. A website designer usually places elements on the page within these thirds for a more interesting and visually appealing layout.
Initial Caps. Avoid placing initial caps in the lower one-third of the page. They tend to draw the eye prematurely to the bottom of the page and visually weigh down or clutter the lower portion of the page.
Single Visual. One of the simplest and perhaps most powerful layouts use one strong visual combined with a strong (usually short) headline plus additional text.
Size. Use larger graphics to communicate the most important goals of the piece. Smaller graphics are of lesser importance. When space is at a premium, drop the smaller elements first — they are less important.